A flexible route to analogues of dihydroimidazo[5,1-a]isoquinolines is described. The synthesis hinges on a sequential Ugi coupling, followed by a Bischler–Napieralski reaction to form the imidazole isoquinoline core. This route facilitates the introduction of a range of substitutions throughout the carbon framework.

中文翻译：

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使用连续的Ugi–Bischler–Napieralski反应序列合成二氢咪唑并[5,1- a ]异喹啉

描述了制备二氢咪唑并[5，1- a ]异喹啉类似物的灵活途径。合成取决于顺序的Ugi偶联，然后进行Bischler-Napieralski反应以形成咪唑异喹啉核心。该途径有助于在整个碳框架中引入一系列取代基。