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5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide; direct preparation, and its application for the synthesis of 5-substituted furan derivatives
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2011-01-12 , DOI: 10.1016/j.tetlet.2011.01.006
Reuben D. Rieke , Seung-Hoi Kim

5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide was easily prepared by the direct insertion of active zinc to 2-bromo-5-(1,3-dioxolane)furan under mild conditions. Of interest, the resulting organozinc was successfully coupled with aryl halides and acid chlorides affording the corresponding coupling products in good to excellent yields.



中文翻译:

5-(1,3-二氧戊环-2-基)-2-呋喃基溴化锌; 直接制备及其在5-取代呋喃衍生物合成中的应用

通过在温和条件下将活性锌直接插入2-溴-5-(1,3-二氧戊环)呋喃中,可以轻松制备5-(1,3-二氧戊环-2-基)-2-呋喃基溴化锌。令人感兴趣的是,将所得的有机锌成功地与芳基卤化物和酰氯偶联,从而以良好或优异的产率提供了相应的偶联产物。

更新日期:2011-01-12
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