A Facile Ion-Doping Strategy to Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics,Journal of the American Chemical Society

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A Facile Ion-Doping Strategy to Regulate Tumor Microenvironments for Enhanced Multimodal Tumor Theranostics
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-12-26 , DOI: 10.1021/jacs.7b11114
Jing Bai ₁ , Xiaodan Jia ₁ , Wenyao Zhen _{1,

2} , Wenlong Cheng ₃ , Xiue Jiang _{1,

2}

Affiliation

Integration of multiple therapeutic/diagnostic modalities into a single system holds great promise to improve theranostic efficiency for tumors, but still remains a technical challenge. Herein, we report a new multimodal theranostic nanoconstruct based on Fe-doped polydiaminopyridine nanofusiforms, built easily and on a large scale, which can dual-regulate intracellular oxygen and glutathione levels, transport iron ions, and simultaneously be used for thermal imaging and magnetic resonance imaging. Co-loading of dihydroartemisinin and methylene blue generates a superior multifunctional theranostic agent with enhanced photochemotherapy efficiency and biodegradability, leading to almost complete destruction of tumors with near-infrared light irradiation. This represents an attractive route to develop multimodal anticancer theranostics.

中文翻译：

一种调节肿瘤微环境的简便离子掺杂策略，用于增强多模式肿瘤治疗诊断

将多种治疗/诊断方式整合到一个系统中有望提高肿瘤的治疗效率，但仍然是一个技术挑战。在此，我们报告了一种基于 Fe 掺杂的聚二氨基吡啶纳米纺锤体的新型多模态治疗诊断纳米结构，该结构易于大规模构建，可以双重调节细胞内氧和谷胱甘肽水平，传输铁离子，同时用于热成像和磁共振成像。双氢青蒿素和亚甲蓝的共同负载产生了一种优异的多功能治疗诊断剂，具有增强的光化学治疗效率和生物降解性，在近红外光照射下几乎可以完全破坏肿瘤。这代表了开发多模式抗癌治疗诊断学的有吸引力的途径。

更新日期：2017-12-26

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