Dibutyl-2-(trifluoromethyl)cyclopropylboronate 2, available in one step from commercially available reagents, serves as a useful (trifluoromethyl)cyclopropylating reagent by participating in a palladium-catalyzed Suzuki coupling. The use of boronate ester 2 in medicinal chemistry was exemplified by preparation of TRPV1 receptor antagonists.

中文翻译：

---

2-（三氟甲基）环丙基硼酸二丁酯作为有用的（三氟甲基）环丙基供体：在TRPV1拮抗剂中的应用

可从市售试剂中一步获得的二丁基-2-（三氟甲基）环丙基硼酸酯2，通过参与钯催化的Suzuki偶联而用作有用的（三氟甲基）环丙基化试剂。通过制备TRPV1受体拮抗剂，举例说明了硼酸酯2在药物化学中的用途。