The efficient cross-coupling of 2-pyridylzinc bromide with functionalized aryl halides has been accomplished by a simple and highly efficient protocol. To the best of our knowledge, we report the first shelf life study of 2-pyridylzinc bromide which confirms the excellent stability of this compound and underlines the synthetic value of organozinc reagents in the cross-coupling reactions of sensitive heterocyclic nucleophiles on academic and commercial scale.

中文翻译：

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Negishi耦合的2-吡啶基溴化锌-交叉耦合化学中的范式转变？

2-吡啶基溴化锌与官能化芳基卤化物的有效交叉偶联已通过简单高效的方案完成。据我们所知，我们首次报告了2-吡啶基溴化锌的货架期研究，该研究证实了该化合物的出色稳定性，并强调了有机锌试剂在敏感的杂环亲核试剂在学术和商业规模上的交叉偶联反应中的合成价值。 。