MBHA (4-methylbenzhydrylamine) resin has been extensively used as a solid support for the synthesis of peptide amides. Herein, we prepared the core–shell-type MBHA resin by benzotriazole-catalyzed amidoalkylation and partial hydrolysis. The core–shell structure of the MBHA resin was confirmed by two-photon microscopy and its synthetic performance in solid-phase peptide synthesis (SPPS) was evaluated.

中文翻译：

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核壳型MBHA树脂的制备及其在固相肽合成中的应用

MBHA（4-甲基苯甲胺）树脂已被广泛用作合成肽酰胺的固体载体。在这里，我们通过苯并三唑催化的酰胺烷基化和部分水解制备了核-壳型MBHA树脂。MBHA树脂的核-壳结构通过双光子显微镜确认，并评估了其在固相肽合成（SPPS）中的合成性能。