2-(Methylamino)nicotinic acid was readily prepared in high yield by reacting 2-chloronicotinic acid with 40% aq MeNH₂ under microwave irradiation either at 120 °C for 2 h or at 140 °C for 1.5 h. Subsequently, we found that a range of 2-aminonicotinic acids could be obtained under microwave heating. The optimal reaction conditions involved the use of 3 equiv of amine, water as the solvent and heating at 200 °C for 2 h in the presence of diisopropylethylamine (3 equiv).

中文翻译：

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2-氯烟酸与胺的微波辅助合成2-氨基烟酸

通过使2-氯烟酸与40％MeNH ₂水溶液在微波辐射下于120°C加热2 h或在140°C加热1.5 h易于制备高产率的2-（甲基氨基）烟酸。随后，我们发现在微波加热下可以获得一定范围的2-氨基烟酸。最佳反应条件包括使用3当量的胺，水作为溶剂，并在二异丙基乙胺（3当量）的存在下于200°C加热2小时。