Efficient syntheses of tripodal thioethers have been achieved by ionic thiol-ene reactions of 1,3,5-triacryloylhexahydro-1,3,5-triazine (TAT) with a variety of commercially available thiols. The reactions are complete within minutes and give the products in high yields (63−96%) and high purity without a complex workup. The thiol-ene reactions tolerate a wide range of functionality, including hydroxy, amino, carboxylate, and trimethoxylsilyl groups. The amino acid cysteine is also an excellent substrate for this reaction.

中文翻译：

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1,3,5-三丙烯酰基六氢-1,3,5-三嗪（TAT）的巯基-烯反应：容易获得功能性三脚架硫醚

三脚架硫醚的有效合成已通过1,3,5-三丙烯酰基六氢-1,3,5-三嗪（TAT）与各种市售硫醇的离子硫醇-烯反应实现。反应在数分钟内完成，无需复杂的后处理即可获得高收率（63-96％）和高纯度的产物。硫醇-烯反应可耐受各种官能团，包括羟基，氨基，羧酸根和三甲氧基甲硅烷基。氨基酸半胱氨酸也是该反应的优良底物。