Mitochondria-targeted ratiometric fluorescent detection of hydrazine with a fast response time†,New Journal of Chemistry

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Mitochondria-targeted ratiometric fluorescent detection of hydrazine with a fast response time†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2017-12-21 00:00:00 , DOI: 10.1039/c7nj04212d
Yanan Ban _{1,

2,

3,

4} , Ruihui Wang _{4,

5,

6,

7} , Yang Li _{1,

2,

3,

4} , Zhen An _{1,

2,

3,

4} , Mingming Yu _{1,

2,

3,

4} , Chenjie Fang _{4,

5,

6,

7} , Liuhe Wei _{1,

2,

3,

4} , Zhanxian Li _{1,

2,

3,

4}

Affiliation

A ratiometric fluorescent probe 1 was synthesized, which exhibited high sensitivity and excellent selectivity for hydrazine recognition. Probe 1 can quantitatively detect hydrazine in the concentration range from 30 to 180 μM with a LOD of 2.1 μM. Furthermore, it displayed excellent selectivity, anti-interference over many nucleophilic species, biological species, metal ions and anions, and a fast response time (4 min). Due to its ability to target mitochondria, the response of hydrazine to this probe in a living cell was successfully tracked in a ratiometric manner via fluorescence imaging.

中文翻译：

线粒体靶向的肼比例荧光检测，响应时间快†

合成了比例荧光探针1，该探针显示出高灵敏度和极好的肼识别选择性。探针1可以定量检测30至180μM浓度范围内的肼，LOD为2.1μM。此外，它显示出优异的选择性，对许多亲核物种，生物物种，金属离子和阴离子的抗干扰性，以及快速的响应时间（4分钟）。由于其靶向线粒体的能力，通过荧光成像成功地按比例跟踪了肼对活细胞中该探针的反应。

更新日期：2017-12-21

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