An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. The described synthesis was used to manufacture 6 kg of the title compound and can also be employed to produce the corresponding (1R)-enantiomer.

中文翻译：

---

对映体纯形式的（1 S）-1-（2,6-二氯-3-氟苯基）乙醇的生物转化介导的合成

描述了一种高效的四步生物转化介导的对映体纯形式的（1 S）-1-（2,6-二氯-3-氟苯基）乙醇的合成。该化合物是制备PF-2341066所需的关键中间体，PF-2341066是目前正在临床开发中的强效c-Met / ALK抑制剂。所描述的合成用于制备6kg的标题化合物，并且还可用于制备相应的（1R）-对映异构体。