A highly efficient asymmetric synthesis of (1S,2R)-2-aminocyclooctanecarboxylic acid has been completed. This asymmetric synthesis using cycloocta-1,5-diene as the starting material is achieved in 77% yield via a four-step sequence from tert-butyl cycloocta-1,7-dienecarboxylate 10 where the extra double bond adjacent to the unsaturated ester is essential to improve the yield. Furthermore, the Michael adduct intermediate (1S,2R,αR)-14 could be used towards the synthesis of the natural product tashiromine.

中文翻译：

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（1 S，2 R）-2-氨基环辛烷羧酸的不对称合成

（1 S，2 R）-2-氨基环辛烷羧酸的高效不对称合成已经完成。使用环辛基-1,5-二烯作为起始原料的这种不对称合成反应可通过四步法从环丁基-1,7-二烯羧酸叔丁酯10中按四个步骤进行，其中邻近不饱和酯的额外双键为对提高产量至关重要。此外，Michael加合物的中间体（1小号，2 - [R，α - [R ）- 14可朝向天然产物tashiromine的合成中使用。