The total synthesis of tunicamycin V is described. This strategy is based on the initial construction of tunicaminyluracil, which is regarded to play an important role in the observed biological activities. The key to the synthesis was a Mukaiyama aldol reaction followed by a furan-oxidation to construct the undecose skeleton, a [3,3] sigmatropic rearrangement of a cyanate, and a highly selective trehalose-type glycosylation.

中文翻译：

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衣霉素V的全合成

描述了衣霉素V的全合成。该策略基于衣氨酰尿嘧啶的初始构建，该构建被认为在观察到的生物活性中起重要作用。合成的关键是Mukaiyama aldol反应，然后进行呋喃氧化以构建十一碳烯骨架，氰酸酯的[3,3]σ重排以及高度选择性的海藻糖型糖基化。