Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol,The Journal of Organic Chemistry

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Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-01-02 00:00:00 , DOI: 10.1021/acs.joc.7b02920
Ren-Jin Tang ₁ , Thierry Milcent ₁ , Benoit Crousse ₁

Affiliation

Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.

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