The enantiomers of Georgywood^® were synthesized from (E)-2-methyl-6-methylene-nona-2,7-diene and methacrylaldehyde followed by oxidation of the Diels–Alder adduct and classical racemate separation of the acid with optically-active N-methylephedrine. Conversion to the final ketone and olfactory evaluation showed that the (−)-(1R,2S)-enantiomer is more powerful by a factor of >100 than its antipode. The absolute configuration was determined by conformational studies and CD-analysis.

中文翻译：

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（-）-（1 R，2 S）-乔治木的合成与嗅觉性能

Georgywood的对映体^®从（合成ê）-2-甲基-6-亚甲基-壬-2,7-二烯和methacrylaldehyde接着狄尔斯-阿尔德加合物和酸的经典外消旋物分离用旋光活性的氧化Ñ -甲基麻黄碱。转化为最终的酮和嗅觉评估表明，（-）-（1 R，2 S）-对映异构体比其对映体的功效高100倍。绝对构型由构象研究和CD分析确定。