We describe a general method for the solid-phase synthesis of cyclic peptides containing an Asp residue in their sequence. Boc-Asp-OFm is linked to PAM resin through the β-carboxylic function; the linear precursor is then assembled by classical Boc/Benzyl strategy. Cyclization is accomplished by the BOP method; HF deprotection and cleavage afford the cyclic peptide as a single product.

中文翻译：

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在固体支持物上合成环肽

我们描述了一种固相合成环肽的常规方法，该环肽在其序列中包含一个Asp残基。Boc-Asp-OFm通过β-羧基官能团连接到PAM树脂上；然后通过经典的Boc / Benzyl策略组装线性前体。环化是通过BOP方法完成的；HF去保护和裂解得到环状肽，为单一产物。