The synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase,Tetrahedron Letters

当前位置： X-MOL 学术 › Tetrahedron Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase
Tetrahedron Letters ( IF 1.5 ) Pub Date : 17 April 1992 , DOI: 10.1016/s0040-4039(00)74189-x
Philip L. Brower , Donald E. Butler , Carl F. Deering , Tung V. Le , Alan Millar , Thomas N. Nanninga , Bruce D. Roth

Three alternative methods for the synthesis of the optically active heptanoate (6), a key intermediate in the preparation of a highly potent and tissue selective HMG Co-A reductase inhibitor are described.

中文翻译：

（4R-顺式）-1,1-二甲基乙基6-氰基甲基-2,2-二甲基-1,3-二恶烷-4-乙酸酯的合成，这是制备强效组织CI-981的关键中间体HMG-CoA还原酶的选择性抑制剂

描述了三种合成光学活性庚酸酯的替代方法（6），庚酸酯是制备高效和组织选择性HMG Co-A还原酶抑制剂的关键中间体。

更新日期：2017-01-31

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南