Synthetic Marine Sponge Collagen by Late-Stage Dihydroxylation,Organic Letters

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Synthetic Marine Sponge Collagen by Late-Stage Dihydroxylation
Organic Letters ( IF 4.9 ) Pub Date : 2017-12-15 00:00:00 , DOI: 10.1021/acs.orglett.7b03525
Christoph Priem ₁ , Armin Geyer ₁

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Based on the observation that an increased substrate size is paralleled by an enhanced diastereoselectivity, a late-stage dihydroxylation protocol toward the 21mer CMP (collagen model peptide) Ac-(Pro-Hyp-Gly)₃-Pro-Dyp-Gly-(Pro-Hyp-Gly)₃-NH₂ is presented. C3 and C4 hydroxylation have a converse effect on the triple-helical stability of collagen. Their combined influence on the melting temperature was studied by NMR spectroscopy.

中文翻译：

后期二羟基化合成海洋海绵胶原蛋白

基于观察到的增加的底物大小与非对映选择性的增强同时出现的是，向21mer CMP（胶原模型肽）Ac-（Pro-Hyp-Gly）₃ -Pro-Dyp-Gly-（Pro -Hyp-Gly）₃ -NH ₂被提出。C3和C4羟基化对胶原蛋白的三螺旋稳定性有相反的影响。通过NMR光谱研究了它们对熔融温度的综合影响。

更新日期：2017-12-15

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