Emerging Nanoclay Composite for Effective Hemostasis,Advanced Functional Materials

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Emerging Nanoclay Composite for Effective Hemostasis
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2017-12-15 , DOI: 10.1002/adfm.201704452
Mei Long _{1,

2} , Yi Zhang _{1,

2} , Peng Huang ₃ , Shi Chang ₃ , Yuehua Hu _{1,

2} , Qian Yang ₄ , Linfeng Mao ₃ , Huaming Yang _{1,

2,

5}

Affiliation

Uncontrolled bleeding following trauma is associated with a high risk of death. Here, an emerging kaolinite nanoclay composite (iron oxide‐kaolinite, α‐Fe₂O₃‐kaolin_KAc) is developed, based on the natural hemostat hematitum used in traditional Chinese medicine to effectively control hemorrhage. α‐Fe₂O₃‐kaolin_KAc stops bleeding in ≈183 ± 16 s and exhibits higher hemostatic activity than the related compounds FeOOH‐kaolin_KAc (298 ± 14 s), γ‐Fe₂O₃‐kaolin_KAc (212 ± 11 s), and Fe₃O₄‐kaolin_KAc (218 ± 15 s). This rapid effect is attributed to efficient absorption of the fluid in blood, activation of blood platelets, and induction of the coagulation cascade by kaolinite and the aggregation of red blood cells induced by α‐Fe₂O₃. α‐Fe₂O₃‐kaolin_KAc shows slight hemolysis (<0.11%) as compared to kaolinite (30%), which accelerates wound healing. The biocompatibility, hemostatic activity, and low cost of α‐Fe₂O₃‐kaolin_KAc make it a safe and effective agent for preventing massive blood loss after traumatic injury.

更新日期：2017-12-15

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