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Carboxylic acid reductase enzymes (CARs)
Current Opinion in Chemical Biology ( IF 6.9 ) Pub Date : 2017-11-09 , DOI: 10.1016/j.cbpa.2017.10.006
Margit Winkler

Carboxylate reductases (CARs) are emerging as valuable catalysts for the selective one-step reduction of carboxylic acids to their corresponding aldehydes. The substrate scope of CARs is exceptionally broad and offers potential for their application in diverse synthetic processes. Two major fields of application are the preparation of aldehydes as end products for the flavor and fragrance sector and the integration of CARs in cascade reactions with aldehydes as the key intermediates. The latest applications of CARs are dominated by in vivo cascades and chemo-enzymatic reaction sequences. The challenge to fully exploit product selectivity is discussed. Recent developments in the characterization of CARs are summarized, with a focus on aspects related to the domain architecture and protein sequences of CAR enzymes.



中文翻译:

羧酸还原酶(CARs)

羧酸还原酶(CARs)作为有价值的催化剂而出现,可用于将羧酸选择性一步还原为相应的醛。CARs的底物范围非常广泛,并为它们在各种合成工艺中的应用提供了潜力。两个主要的应用领域是制备醛,将其用作香料和香料行业的最终产品,以及将CARs与以醛为主要中间体的级联反应相结合。汽车的最新应用主要是在体内级联和化学酶促反应序列。讨论了充分利用产品选择性的挑战。总结了CAR表征的最新进展,重点是与CAR酶的结构域结构和蛋白质序列有关的方面。

更新日期:2018-06-03
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