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When Clarity Is Crucial: Regulating Ocular Surface Immunity
Trends in Immunology ( IF 13.1 ) Pub Date : 2017-12-13 00:00:00 , DOI: 10.1016/j.it.2017.11.007 William Foulsham 1 , Giulia Coco 2 , Afsaneh Amouzegar 2 , Sunil K Chauhan 2 , Reza Dana 2
Trends in Immunology ( IF 13.1 ) Pub Date : 2017-12-13 00:00:00 , DOI: 10.1016/j.it.2017.11.007 William Foulsham 1 , Giulia Coco 2 , Afsaneh Amouzegar 2 , Sunil K Chauhan 2 , Reza Dana 2
Affiliation
The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflammation at the cornea – blindness. Recent data have elucidated the contributions of specific anatomical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the ocular surface. We highlight research trends at this distinctive mucosal barrier and identify crucial gaps in our current knowledge.
中文翻译:
当清晰度至关重要时:调节眼表免疫力
眼表面是一个独特的粘膜免疫区室,其中解剖学、生理学和免疫学特征协同作用,形成一个特别耐受的微环境。这些机制对于眼睛的功能至关重要,角膜过度炎症造成的毁灭性后果——失明就凸显了这一事实。最近的数据阐明了特定解剖成分、免疫细胞和可溶性免疫调节因子在促进眼表稳态中的贡献。我们重点介绍了这种独特的粘膜屏障的研究趋势,并确定了我们当前知识中的关键差距。
更新日期:2017-12-15
中文翻译:
当清晰度至关重要时:调节眼表免疫力
眼表面是一个独特的粘膜免疫区室,其中解剖学、生理学和免疫学特征协同作用,形成一个特别耐受的微环境。这些机制对于眼睛的功能至关重要,角膜过度炎症造成的毁灭性后果——失明就凸显了这一事实。最近的数据阐明了特定解剖成分、免疫细胞和可溶性免疫调节因子在促进眼表稳态中的贡献。我们重点介绍了这种独特的粘膜屏障的研究趋势,并确定了我们当前知识中的关键差距。