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The 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl group (Pbf) as arginine side chain protectant
Tetrahedron Letters ( IF 1.5 ) Pub Date : 3 December 1993 , DOI: 10.1016/s0040-4039(00)61487-9
Louis A. Carpino , Hitesh Shroff , Salvatore A. Triolo , El-Sayed M.E. Mansour , Holger Wenschuh , Fernando Albericio

The 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl residue (Pbf) is more easily deblocked by trifluoroacetic acid (TFA) than the corresponding Pmc analog and can be used efficiently in the synthesis of arginine-containing peptides.

中文翻译:

2,2,4,6,7-五甲基二氢苯并呋喃-5-磺酰基(Pbf)作为精氨酸侧链保护剂

与相应的Pmc类似物相比,2,2,4,6,7-五甲基二氢苯并呋喃-5-磺酰基残基(Pbf)更容易被三氟乙酸(TFA)解封,并且可以有效地用于合成含精氨酸的肽。
更新日期:2017-01-31
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