A flexible, convergent synthesis of Cyclotheonamide B (1b) was developed, starting from the constituent amino acids, using conventional benzyl-, t-butyl- and allyl-based protecting groups. By modification of the key intermediates, this approach allows the preparation of cyclotheonamide analogues.

中文翻译：

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全合成环乙酰胺B，一条通往类似物的捷径

使用传统的基于苄基，叔丁基和烯丙基的保护基团，从组成氨基酸开始，开发了一种柔性，收敛的Cyclotheonamide B（1b）合成方法。通过修饰关键中间体，该方法允许制备环乙酰胺类似物。