A novel ternary composite, Cu/Cu₂O/CuO hollow spheres (HSs), synthesized using an aerosol furnace reactor (FuAR) was investigated for the first time as a non-enzymatic electrochemical biosensor for glucose detection. The composite HSs were synthesized by aerosolizing a mixture of copper nitrate, citric acid, and ammonia through a FuAR. Interestingly, the addition of ammonia played a crucial role in the in-situ formation of hollow Cu/Cu₂O/CuO ternary composites. The HSs modified electrode was employed for non-enzymatic glucose detection where it exhibited a detection limit of 0.39 μM and an outstanding sensitivity of 8726 μA cm⁻² mM⁻¹ which is superior to existing Cu/Cu₂O HSs and CuO HSs modified electrodes. The high sensitivity was attributed to the synergy arising from the ternary composition’s interfacing with multiple Cu redox couples and high surface area. The Cu/Cu₂O/CuO HSs modified electrode also showed excellent selectivity in detecting glucose in the presence of interfering species, including chloride salts of Na⁺, K⁺, Ca²⁺, and anions of ascorbic acid (AA), dopamine (DA), and uric acid (UA). This simple and scalable FuAR technique will attract interest and enable in designing other high-performance metal/metal oxide composites for commercial glucose sensing applications.

首次研究了使用气溶胶炉反应器（FuAR）合成的新型三元复合材料Cu / Cu ₂ O / CuO中空球（HSs）作为用于葡萄糖检测的非酶电化学生物传感器。通过通过FuAR雾化硝酸铜，柠檬酸和氨的混合物来合成复合HS。有趣的是，添加氨在中空Cu / Cu ₂ O / CuO三元复合材料的原位形成中起着关键作用。HSs修饰电极用于非酶法葡萄糖检测，其检测极限为0.39μM，出色的灵敏度为8726μAcm ^-2  mM ^-1，优于现有的Cu / Cu ₂O HSs和CuO HSs修饰电极。高灵敏度归因于三元组成与多个Cu氧化还原对和高表面积的界面所产生的协同作用。Cu / Cu ₂ O / CuO HSs修饰电极在存在干扰物质（包括Na ⁺，K ⁺，Ca ^2+的氯化物盐和抗坏血酸（AA）的阴离子，多巴胺（ DA）和尿酸（UA）。这种简单且可扩展的FuAR技术将引起人们的兴趣，并能够设计出用于商业葡萄糖传感应用的其他高性能金属/金属氧化物复合材料。