A new industrial process, involving only two isolation and drying steps, for 10-methoxyiminostilbene (MISB), an advance intermediate of widely prescribed antiepileptic drug, oxcarbazepine, has been developed. A salient feature of this process is the novel use of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) to afford bromohydrin methyl ether from N-acetyliminostilbene. The byproducts of this process namely acetic acid, 5,5-dimethylhydantoin and Et₃N·HBr are recyclable as well as nontoxic. This process is amenable for the large-scale production of MISB.

中文翻译：

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10-甲氧基亚氨基二苯乙烯的新工业工艺：合成奥卡西平的关键中间体

已开发出一种新的工业工艺，仅涉及两个分离和干燥步骤，即10-甲氧基亚氨基二苯乙烯（MISB），这是广泛使用的抗癫痫药奥卡西平的高级中间体。该方法的显着特征是新颖地使用1，3-二溴-5，5-二甲基乙内酰脲（DBDMH）从N-乙酰基亚氨基二苯乙烯制得溴代醇甲基醚。该方法的副产物，即乙酸，5,5-二甲基乙内酰脲和Et ₃ N·HBr可回收且无毒。该工艺适合于MISB的大规模生产。