A simple, efficient synthesis of 2-(1,2-dithiolan-3-yl)acetic acid from Meldrum's acid, acrolein and thioacetic acid is described. The isopropyldene 2,4-bis(acetylthio)butane-1,1-dicarboxylate formed in the three-component, single container process, can be methanolized to the corresponding dimethyl ester and then hydrolyzed, oxidized to the disulfide and decarboxylated to 2-(1,2-dithiolan-3-yl)acetic acid. The acid can be converted by conventional reagents into a variety of amide derivatives.

中文翻译：

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一种高效的合成2-（1,2-二硫杂环戊基-3-基）乙酸的途径。三去硫辛酸和酰胺衍生物

描述了从麦德鲁姆的酸，丙烯醛和硫代乙酸简单，有效地合成2-（1,2-二硫杂环戊-3-基）乙酸。在三组分，单容器工艺中形成的异丙基2,4-双（乙酰硫基）丁烷-1,1-二羧酸酯可以甲醇化为相应的二甲酯，然后水解，氧化为二硫化物并脱羧为2-（ 1,2-二硫代木兰-3-基）乙酸。可以通过常规试剂将酸转化为各种酰胺衍生物。