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Novel synthesis of 3-(3,3,3-trifluoroprop-1-en-2-yl)furans via stereoselective processing and palladium-catalyzed cycloisomerization
Tetrahedron Letters ( IF 1.5 ) Pub Date : 12 March 2007 , DOI: 10.1016/j.tetlet.2007.01.097 Jiming Zhang , Xiaoming Zhao , Long Lu
Tetrahedron Letters ( IF 1.5 ) Pub Date : 12 March 2007 , DOI: 10.1016/j.tetlet.2007.01.097 Jiming Zhang , Xiaoming Zhao , Long Lu
The 3,3,3-trifluoroprop-1-en-2-yl-substituted furans (4) were synthesized via palladium-catalyzed cyclization–isomerization of 1,1,1-trifluoro-2-[(tert-butyldimethylsilyloxy)methyl]-3-alkynylbut-2-en-1-ols (3), which were readily obtained from 1,1,1-trifluoro-2-[(tert-butyldimethylsilyloxy)methyl]-3,3-dibromoprop-2-ene (1) in three steps.
中文翻译:
通过立体选择性处理和钯催化的环异构化新型合成3-(3,3,3-三氟丙-1-烯-2-基)呋喃
通过钯催化的1,1,1-三氟-2-[(叔丁基二甲基甲硅烷氧基)甲基]的环化-异构化反应合成了3,3,3-三氟丙-1-烯-2-基取代的呋喃(4)。-3- alkynylbut -2-烯-1-醇(3),将其容易地从1,1,1-三氟-2-得到- [(叔-butyldimethylsilyloxy)甲基] -3,3- dibromoprop -2-烯(1)分三步。
更新日期:2017-01-31
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
通过立体选择性处理和钯催化的环异构化新型合成3-(3,3,3-三氟丙-1-烯-2-基)呋喃
通过钯催化的1,1,1-三氟-2-[(叔丁基二甲基甲硅烷氧基)甲基]的环化-异构化反应合成了3,3,3-三氟丙-1-烯-2-基取代的呋喃(4)。-3- alkynylbut -2-烯-1-醇(3),将其容易地从1,1,1-三氟-2-得到- [(叔-butyldimethylsilyloxy)甲基] -3,3- dibromoprop -2-烯(1)分三步。