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Convenient synthesis of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics
Tetrahedron Letters ( IF 1.5 ) Pub Date : 18 June 2001 , DOI: 10.1016/s0040-4039(01)00612-8 Jinquan Yu , Jonathan B Spencer
Tetrahedron Letters ( IF 1.5 ) Pub Date : 18 June 2001 , DOI: 10.1016/s0040-4039(01)00612-8 Jinquan Yu , Jonathan B Spencer
2-Deoxy-scyllo-inosose 1 and 2-deoxy-scyllo-inosamine 2 are two of the key intermediates on the biosynthetic pathway to 2-deoxystreptamine-containing aminoglycoside antibiotics. Convenient syntheses of 1, 2 and tritium-labelled 2 via stereoselective deoxygenation of myo-inositol using LTBH are reported. This should provide the substrates necessary for characterising the enzymes involved on the biosynthetic pathway.
中文翻译:
方便合成的2-脱氧青蟹-inosose和2-脱氧青蟹-inosamine:对生物合成途径的氨基糖苷类抗生素的两个关键中间体
2-脱氧青蟹-inosose 1和2-脱氧青蟹-inosamine 2是含2脱氧链霉胺氨基糖苷类抗生素两个在生物合成途径中的关键中间体的对。的方便合成1,2和氚标记的2经由立体选择性脱氧肌使用LTBH肌醇报告。这应该提供表征生物合成途径所涉及的酶所必需的底物。
更新日期:2017-01-31
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
方便合成的2-脱氧青蟹-inosose和2-脱氧青蟹-inosamine:对生物合成途径的氨基糖苷类抗生素的两个关键中间体
2-脱氧青蟹-inosose 1和2-脱氧青蟹-inosamine 2是含2脱氧链霉胺氨基糖苷类抗生素两个在生物合成途径中的关键中间体的对。的方便合成1,2和氚标记的2经由立体选择性脱氧肌使用LTBH肌醇报告。这应该提供表征生物合成途径所涉及的酶所必需的底物。