2-(Trifluoromethyl)furanones were obtained in good yields via the Claisen condensation of acetophenones with methyl 2-methoxytetrafluoropropionate, followed by sulfuric acid-mediated deprotection of the reaction products. These compounds react with 2,3-diaminopyridine, o-phenylenediamine and 2,3-diaminonaphthalene in refluxing acetic acid to give the corresponding quinoxaline derivatives, the regioisomeric and tautomeric composition of which was investigated. Reactions of 2-(trifluoromethyl)furanones with hydrazines and hydroxylamine proceeded regioselectively and gave pyridazine, pyrazole and isoxazole derivatives in high yields. Their regiochemistry was established by X-ray diffraction analysis.

中文翻译：

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5-芳基-2-羟基-2-（三氟甲基）呋喃-3（2H）-的合成及其与芳族1,2-二胺，肼和羟胺的反应

通过苯乙酮与2-甲氧基四氟丙酸甲酯的克莱森缩合，然后用硫酸介导的反应产物脱保护，以高收率获得了2-（三氟甲基）呋喃酮。这些化合物与2，3-二氨基吡啶，邻苯二胺和2，3-二氨基萘在回流的乙酸中反应，得到相应的喹喔啉衍生物，研究了它们的区域异构和互变异构组成。2-（三氟甲基）呋喃酮与肼和羟胺的反应区域选择性地进行，并以高收率得到哒嗪，吡唑和异恶唑衍生物。通过X射线衍射分析确定了它们的区域化学。