Synthesis of N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-Protected (Fmoc) β-Amino Acids (= homo-α-amino acids) by direct homologation,Helvetica Chimica Acta

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Synthesis of N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-Protected (Fmoc) β-Amino Acids (= homo-α-amino acids) by direct homologation
Helvetica Chimica Acta ( IF 1.5 ) Pub Date : 25 OCT 2004 , DOI: 10.1002/hlca.19980810107
Ernst P. Ellmerer‐Müller , Dagmar Brössner , Najib Maslouh , Andreas Takó

The successful application of the Arndt-Eistert protocol starting from commercially available N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-protected (Fmoc) α-amino acids leading to enantiomerically pure N-Fmoc-protected β-amino acids in only two steps and with high yield is reported.

中文翻译：

通过直接同源法合成N -{[（9 H-氟9-基）甲氧基]羰基}保护的（Fmoc）β-氨基酸（=均α-氨基酸）

Arndt-Eistert方案的成功应用始于可商购的N -{[（9 H-氟-9-基）甲氧基]羰基}保护的（Fmoc）α-氨基酸，产生对映体纯的N -Fmoc保护的β报道了仅两步且高收率的β-氨基酸。

更新日期：2017-01-31

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