成骨细胞的寿命和功能不断扩展：从简单的造骨细胞到多功能细胞,Journal of Bone and Mineral Research

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成骨细胞的寿命和功能不断扩展：从简单的造骨细胞到多功能细胞
Journal of Bone and Mineral Research ( IF 5.1 ) Pub Date : 2017-12-05 , DOI: 10.1002/jbmr.3356
Pierre J Marie _{1,

2} , Martine Cohen-Solal _{1,

2}

Affiliation

在过去的三十年中，骨细胞生物学以及人类和小鼠遗传学的重要进展导致我们对成骨细胞谱系细胞的生命和功能的了解有了重大进展。以前已经发现了无法识别的成骨细胞来源。已经确定了控制成骨细胞分化和衰老的新型细胞和分子机制。已经确定了成骨细胞，骨细胞，破骨细胞和软骨细胞之间通信的新机制，以及成骨细胞与血管之间的新型联系。此外，成骨细胞谱系的细胞被证明是造血生态位的重要组成部分，并与血液功能障碍和恶性肿瘤有关。最后，通过释放旁分泌因子，在成骨细胞与包括中枢神经系统，肠，肌肉，脂肪和睾丸在内的若干软组织之间发现了意想不到的相互作用，这使成骨细胞除了具有造骨功能外，还具有多功能的调节细胞。这些发现极大地扩大了我们对成骨细胞的生命和功能的视野，这可能导致开发出可立即应用于骨骼疾病的新型疗法。本文受版权保护。版权所有这可能会导致在骨骼疾病中立即应用的新型疗法的发展。本文受版权保护。版权所有这可能会导致在骨骼疾病中立即应用的新型疗法的发展。本文受版权保护。版权所有

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The expanding life and functions of osteogenic cells: From simple bone making cells to multifunctional cells and beyond

During the last three decades, important progresses in bone cell biology and in human and mouse genetics led to major advances in our understanding of the life and functions of cells of the osteoblast lineage. Previously unrecognized sources of osteogenic cells have been identified. Novel cellular and molecular mechanisms controlling osteoblast differentiation and senescence have been determined. New mechanisms of communications between osteogenic cells, osteocytes, osteoclasts and chondrocytes, as well as novel links between osteogenic cells and blood vessels have been identified. Additionally, cells of the osteoblast lineage were shown to be important components of the hematopoietic niche and to be implicated in hematologic dysfunctions and malignancy. Lastly, unexpected interactions were found between osteogenic cells and several soft tissues including the central nervous system, gut, muscle, fat and testis through the release of paracrine factors, making osteogenic cells multifunctional regulatory cells, in addition to their bone making function. These discoveries considerably enlarged our vision of the life and functions of osteogenic cells, which may lead to the development of novel therapeutics with immediate applications in bone disorders. This article is protected by copyright. All rights reserved

更新日期：2017-12-14

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