A synthesis of (R)‐muscone (1), a valuable musk odorant, is presented. The stereogenic center of muscone was introduced from methyl (R)‐5‐bromo‐4‐methylpentanoate (5), a chiral pool molecule developed in our group, and the macrocyclic ring was prepared by ring‐closing metathesis (RCM) reaction.

中文翻译：

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由（R）-5-溴-4-甲基戊酸酯合成（R）-（-）-Muscone：Chiron方法

本文介绍了一种有价值的麝香加味剂（R）-muscone（1）的合成。muscone的立体异构中心是由我们小组开发的手性池分子（R）-5-溴-4-甲基戊酸（5）引入的，并通过闭环易位（RCM）反应制备了大环。