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Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum
Organic Letters ( IF 4.9 ) Pub Date : 2015-10-01 00:00:00 , DOI: 10.1021/acs.orglett.5b02515
Hai-Bing Liao 1 , Chun Lei 1 , Li-Xin Gao 2 , Jing-Ya Li 2 , Jia Li 2 , Ai-Jun Hou 1
Affiliation  

Two enantiomeric pairs of meroterpenoids, (−)- and (+)-rhodonoids A (1a and 1b) and B (2a and 2b), were isolated unprecedentedly from partially racemic mixtures that naturally occurred in Rhododendron capitatum. Their structures were fully determined by spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. Compounds 1a and 1b are the first examples of meromonoterpenes featuring a unique 6/6/6/4 ring system. Compounds 2a and 2b showed PTP1B inhibitory activity.

中文翻译:

杜鹃花的类对萜类化合物的两个对映异构体对

两种对映体对的meroterpenoids,( - ) -和(+) - rhodonoids A(1A1B)和B(图2a图2b),进行了空前从天然发生的部分外消旋混合物中分离花杜鹃。它们的结构完全由光谱数据,X射线晶体学和电子圆二色性分析确定。化合物1a1b是具有独特6/6/6/4环系统的单萜的首个实例。化合物2a2b显示出PTP1B抑制活性。
更新日期:2015-10-01
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