In vivo THz imaging of human skin: Accounting for occlusion effects,Journal of Biophotonics

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In vivo THz imaging of human skin: Accounting for occlusion effects
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2017-10-04 , DOI: 10.1002/jbio.201700111
Qiushuo Sun ₁ , Edward P.J. Parrott ₁ , Yuezhi He ₁ , Emma Pickwell-MacPherson ₁

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In vivo terahertz (THz) imaging of human skin needs to be done in reflection geometry due to the high attenuation of THz light by water in the skin. To aid the measurement procedure, there is typically an imaging window onto which the patient places the area of interest. The window enables better pulse alignment and helps keep the patient correctly positioned during the measurement. In this paper, we demonstrate how the occlusion caused by the skin contact with the imaging window during the measurement affects the THz response. By studying both rapid point measurements and imaging over an area of a human volar forearm, we find that even 5 seconds of occlusion affects the THz response. As the occlusion time increases, the skin surface water content increases, resulting in the reduction of the amplitude of the reflected THz pulse, especially in the first 3 minutes. Furthermore, it was found that the refractive index of the volar forearm increased by 10% to 15% after 20 minutes of occlusion. In this work, we examine and propose a model for the occlusion effects due to the quartz window with a view to compensating for its influence.

中文翻译：

人体皮肤的体内太赫兹成像：遮挡效应的解释

由于皮肤中水对太赫兹光的高度衰减，因此需要在反射几何图形中完成人体皮肤的体内太赫兹（THz）成像。为了帮助进行测量，通常有一个成像窗口，患者可以将感兴趣的区域放在成像窗口上。该窗口可实现更好的脉冲对准，并有助于在测量过程中使患者保持正确的位置。在本文中，我们演示了在测量过程中皮肤与成像窗口的接触所引起的阻塞如何影响THz响应。通过研究人类手掌前臂区域的快速点测量和成像，我们发现即使闭塞5秒钟也会影响THz响应。随着阻塞时间的增加，皮肤表面的水分含量增加，从而导致反射的太赫兹脉冲幅度减小，尤其是在前3分钟内。此外，发现在闭塞20分钟后掌侧前臂的折射率增加了10％至15％。在这项工作中，我们检查并提出了一个由石英窗引起的闭塞效应的模型，以补偿其影响。

更新日期：2017-10-04

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