使用近红外激光激活的热敏脂质体包裹的阿霉素和金纳米棒治疗淋巴结中的肿瘤,Journal of Biophotonics

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使用近红外激光激活的热敏脂质体包裹的阿霉素和金纳米棒治疗淋巴结中的肿瘤
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2017-04-18 , DOI: 10.1002/jbio.201600241
Daisuke Matsuki _{1,

2} , Oladipo Adewale ₃ , Sachiko Horie _{1,

2} , Junnosuke Okajima ₄ , Atsuki Komiya ₄ , Oluwatobi Oluwafemi ₃ , Shigenao Maruyama ₄ , Shiro Mori _{1,

2,

5} , Tetsuya Kodama _{1,

2}

Affiliation

尽管癌症治疗最近有所发展，但肿瘤转移至淋巴结是导致癌症相关死亡的重要因素。在这项研究中，我们证明可以通过应用外部激光来触发小鼠的适当腋窝淋巴结（PALN）中的肿瘤，以触发与金一起施用的热敏脂质体（TSL）中封装的阿霉素（DOX）的卸载纳米棒（GNR）。将GNRs + DOX‐TSLs注入含有癌细胞（恶性纤维组织细胞瘤样细胞）的小鼠淋巴结中，并通过近红外（NIR）激光辐照激活结节内DOX释放。激光照射的GNR引起的温度变化触发了TSL中DOX的释放。与其他组相比，共治疗组对肿瘤生长的抑制作用更大。通过化学疗法和近红外激活热疗相结合可达到治疗效果。体内生物发光成像和组织学分析证实了对联合治疗的肿瘤坏死。这项工作提出了一种具有优异治疗效果的治疗学方法，有可能被发展为手术治疗乳腺癌转移的替代方法。

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Treatment of tumor in lymph nodes using near‐infrared laser light‐activated thermosensitive liposome‐encapsulated doxorubicin and gold nanorods

Tumor metastasis to lymph nodes is an important contributory factor for cancer‐related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX‐TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma‐like cells) and intranodal DOX release was activated using near‐infrared (NIR) laser irradiation. The temperature changes arising from the laser‐irradiated GNRs triggered the release of DOX from the TSLs. A greater degree of inhibition of tumor growth was found in the co‐therapy group compared to the other groups. The treatment effect was achieved by a combination of chemotherapy and NIR‐activated hyperthermia. In vivo bioluminescence imaging and histological analysis confirmed tumor necrosis in response to combined treatment. This work presents a theranostic approach with excellent treatment results that has the potential to be developed into an alternative to surgery for the treatment of breast cancer metastasis.

更新日期：2017-04-18

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