Atomically Precise Au25(SG)18 Nanoclusters: Rapid Single-Step Synthesis and Application in Photothermal Therapy,ACS Applied Materials & Interfaces

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Atomically Precise Au25(SG)18 Nanoclusters: Rapid Single-Step Synthesis and Application in Photothermal Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-12-20 00:00:00 , DOI: 10.1021/acsami.7b12614
Sai Krishna Katla ₁ , Jie Zhang ₁ , Edison Castro ₁ , Ricardo A Bernal ₁ , XiuJun Li ₁

Affiliation

Remarkable recent advances on Au₂₅(SR)₁₈ nanoclusters have led to significant applications in catalysis, sensing, and magnetism. However, the existing synthetic routes are complicated, particularly for the water-soluble Au₂₅(SG)₁₈ nanoclusters. Here, we report a single-step concentration and temperature-controlled method for rapid synthesis of the Au₂₅(SG)₁₈ nanoclusters in as little as 2 h without the need for low-temperature reaction or even stirring. A systematic time-based investigation was carried out to study the effects of volume, concentration, and temperature on the synthesis of these nanoclusters. Further, we discovered for the first time that the Au₂₅(SG)₁₈ nanoclusters exhibit excellent photothermal activities in achieving 100% cell death for MDA-MB-231 breast cancer cells at a power of 10 W/cm² using an 808 nm laser source, demonstrating applications toward photothermal therapy.

中文翻译：

原子级精度的 Au25(SG)18 纳米团簇：快速单步合成及其在光热治疗中的应用

_{Au 25} (SR) ₁₈纳米团簇最近取得的显着进展已在催化、传感和磁性等方面取得重要应用。然而，现有的合成路线很复杂，特别是对于水溶性 Au ₂₅ (SG) ₁₈纳米团簇。在这里，我们报告了一种单步浓缩和温度控制的方法，可在短短 2 小时内快速合成 Au ₂₅ (SG) ₁₈纳米团簇，无需低温反应甚至搅拌。进行了系统的基于时间的调查，以研究体积、浓度和温度对这些纳米团簇合成的影响。此外，我们首次发现 Au ₂₅(SG) _{18 个}纳米团簇在使用 808 nm 激光源以 10 W/cm ²的功率实现 MDA-MB-231 乳腺癌细胞 100% 的细胞死亡方面表现出优异的光热活性，展示了在光热治疗方面的应用。

更新日期：2017-12-20

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