The first total synthesis of (+)-vibsanin A, an 11-membered vibsane diterpenoid, was achieved, unambiguously establishing its relative and absolute stereochemistry. Highlights of the synthesis include the stereoselective formation of an all-carbon quaternary stereocenter by a zinc-mediated Barbier-type allylation in an aqueous medium, and the efficient construction of an 11-membered ring skeleton by a combination of an intramolecular Nozaki–Hiyama–Kishi (NHK) reaction and a Mitsunobu reaction.

中文翻译：

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（+）-Vibsanin A的全合成

实现了第一个全合成的（+）-vibsanin A（一种11元的visane二萜类化合物），明确地建立了其相对和绝对立体化学。合成的亮点包括在水介质中通过锌介导的Barbier型烯丙基化立体选择性地形成全碳四级立体中心，以及结合分子内的Nozaki–Hiyama–高效构建11元环骨架Kishi（NHK）反应和Mitsunobu反应。