Nickel-catalyzed amination of aryl fluorides with primary amines,Chemical Communications

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Nickel-catalyzed amination of aryl fluorides with primary amines
Chemical Communications ( IF 4.3 ) Pub Date : 2017-12-12 00:00:00 , DOI: 10.1039/c7cc08181b
Tomoya Harada _{1,

2,

3,

4,

5} , Yusuke Ueda _{1,

2,

3,

4,

5} , Tomohiro Iwai _{1,

2,

3,

4,

5} , Masaya Sawamura _{1,

2,

3,

4,

5}

Affiliation

The Ni-catalyzed cross-coupling reaction between aryl fluorides and primary amines was enabled by the 1,2-bis(dicyclohexylphosphino)benzene (DCYPBz) or 1,2-bis(dicyclohexylphosphino)ethane (DCYPE) ligands. Both N-alkyl- and N-aryl-substituted primary amines participated in the selective reaction to form secondary amines. This protocol would potentially be useful for late-stage diversification of fluorinated compounds with complex structures for the synthesis of functionally interesting aniline derivatives.

中文翻译：

伯胺在镍催化的芳基氟化胺上的胺化反应

1,2-双（二环己基膦基）苯（DCYPBz）或1,2-双（二环己基膦基）乙烷（DCYPE）配体可实现芳基氟化物与伯胺之间的镍催化交叉偶联反应。既Ñ -烷基-和Ñ参与选择性反应-芳基取代的伯胺，以形成仲胺。该方案对于具有复杂结构的氟化化合物的后期分散化可能很有用，以合成功能上有意义的苯胺衍生物。

更新日期：2018-02-14

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