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Phototriggered N2-Generating Submicron Particles for Selective Killing of Cancer Cells
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-12-18 00:00:00 , DOI: 10.1021/acsami.7b16362
Huiying Li 1 , Wenbo Zhang 1 , Ning He 1 , Weijun Tong 1 , Changyou Gao 1
Affiliation  

Killing of cancer cells by applying mechanical disruption has been an appealing emerging strategy for cancer treatment in recent years. In this study, photoresponsive submicron particles based on diazo-resin that are able to release N2 under UV irradiation were prepared through a polyamine–salt aggregation method. After surface modification with hyaluronic acid, the particles could be internalized selectively by cancer cells and were mainly located in lysosomes after 6 h incubation. The viability of cancer cells decreased obviously after they were co-cultured with photoresponsive particles and UV irradiation due to the integrity damage of lysosomes by phototriggered N2 generation and the subsequent increased number of reactive oxygen species.

中文翻译:

光触发的N 2生成亚微米颗粒用于选择性杀死癌细胞

近年来,通过机械破坏杀死癌细胞已成为一种有吸引力的新兴癌症治疗策略。在这项研究中,通过多胺盐聚集法制备了基于重氮树脂的能够在紫外线照射下释放N 2的光敏亚微米颗粒。经透明质酸表面修饰后,颗粒可被癌细胞选择性内在化,孵育6小时后主要位于溶酶体中。癌细胞与光敏颗粒共培养和紫外线照射后,其活力由于光触发的N 2生成对溶酶体的完整性破坏以及随后活性氧数量的增加而明显降低。
更新日期:2017-12-18
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