Fragaria x ananassa Duch., popularly called strawberry, is known for its worldwide consumption and important biological activities, and these effects are related to its high concentration of anthocyanins. Pelargonidin-3-O-glucoside (P3G) is a major anthocyanin found in strawberry, and was evaluated for its anti-inflammatory action in experimental models. The effect of strawberry extract and P3G, on leukocyte migration, exudation levels and many inflammatory mediators, was therefore evaluated in an in vivo model. An in vitro study was also carried out to characterize the effect of P3G on mitogen-activated protein kinases, and on nuclear transcript factors NF-κB and AP-1. The results revealed that the strawberry and P3G have important anti-inflammatory proprieties, and the anti-inflammatory mechanism of P3G involves the arrest of IkB-α activation and reduction in JNK^MAPK phosphorylation. The results reinforce that strawberry fruits are functional foods that can act as an adjuvant in the treatment of inflammatory conditions.

Fragaria x ananassa Duch，俗称草莓，因其全球消费和重要的生物活性而闻名，这些影响与其花青素的高浓度有关。Pelargonidin-3- O - glucoside（P3G）是草莓中发现的主要花色苷，并在实验模型中对其抗炎作用进行了评估。因此，在体内模型中评估了草莓提取物和P3G对白细胞迁移，渗出水平和许多炎症介质的影响。一种在体外还进行了研究以鉴定P3G对促分裂原活化蛋白激酶，核转录因子NF-κB和AP-1的作用。结果表明，草莓和P3G具有重要的抗炎特性，P3G的抗炎机制涉及IkB-α的活化和JNK ^MAPK磷酸化的降低。结果表明，草莓果实是功能性食品，可以作为炎症性疾病的佐剂。