Dynamic Ligand Exchange as a Mechanistic Probe in Pd-Catalyzed Enantioselective C-H Functionalization Reactions Using Monoprotected Amino Acid Ligands,Journal of the American Chemical Society

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Dynamic Ligand Exchange as a Mechanistic Probe in Pd-Catalyzed Enantioselective C-H Functionalization Reactions Using Monoprotected Amino Acid Ligands
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-12-14 , DOI: 10.1021/jacs.7b11962
David E. Hill ₁ , Katherine L. Bay ₂ , Yun-Fang Yang ₂ , R. Erik Plata ₁ , Ryosuke Takise ₃ , K. N. Houk ₂ , Jin-Quan Yu ₁ , Donna G. Blackmond ₁

Affiliation

A new tool for probing enantioselective reaction mechanisms is introduced. Monitoring the temporal change in product enantiomeric excess after addition of the opposite enantiomer of the ligand during the reaction provides a means of probing dynamic ligand exchange in enantioselective C-H iodination catalyzed by Pd with monoprotected amino acid ligands (MPAAs). This work has general potential to provide insights about the dynamics of catalyst and ligand molecularity and exchange.

中文翻译：

动态配体交换作为 Pd 催化的对映选择性 CH 官能化反应中使用单保护氨基酸配体的机制探针

介绍了一种用于探测对映选择性反应机制的新工具。在反应过程中添加配体的相反对映体后，监测产物对映体过量的时间变化提供了一种在 Pd 与单保护氨基酸配体 (MPAA) 催化的对映选择性 CH 碘化中探测动态配体交换的方法。这项工作具有普遍的潜力，可以提供有关催化剂和配体分子和交换动力学的见解。

更新日期：2017-12-14

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