Three limonoids named thaixylomolins A–C (1–3), featuring two new motifs, were isolated from the seeds of a Thai mangrove, Xylocarpus moluccensis. The absolute configurations of these limonoids were determined by extensive NMR investigations, single-crystal X-ray diffraction analysis, and circular-dichroism spectroscopy in combination with quantum-chemical calculations. Thaixylomolin B exhibited inhibitory activity against nitric oxide production in lipopolysaccharide and IFN-γ-induced RAW264.7 murine macrophages with an IC₅₀ value of 84.3 μM.

中文翻译：

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Thaixylomolins A–C：具有来自泰国Xylocarpus moluccensis的两个新基序的柠檬苦素

三个柠檬苦素名为thaixylomolins A-C（1 - 3），具有两个新的主题，从泰国的红树林，种子里分离出木果moluccensis。这些柠檬苦素的绝对构型是通过广泛的NMR研究，单晶X射线衍射分析和圆二色性光谱结合量子化学计算确定的。Thaixylomolin B在脂多糖和IFN-γ诱导的RAW264.7鼠巨噬细胞中表现出对一氧化氮产生的抑制活性，IC ₅₀值为84.3μM。