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Compounds from Acorus tatarinowii: Determination of Absolute Configuration by Quantum Computations and cAMP Regulation Activity
Journal of Natural Products ( IF 3.3 ) Pub Date : 2010-05-17 00:00:00 , DOI: 10.1021/np900793e
Xiao-Gang Tong 1 , Gui-Sheng Wu 1 , Cheng-Gang Huang 1 , Qing Lu 1 , Yue-Hu Wang 1 , Chun-Lin Long 1 , Huai-Rong Luo 1 , Hua-Jie Zhu 1 , Yong-Xian Cheng 1
Affiliation  

A new cadinane-type sesquiterpenoid, tatarinowin A (1), two phenylpropanoids, tatarinoids A (2) and B (3), and a trinorlignan, tatarinoid C (4), along with 15 known compounds including two pairs of mixtures were isolated from the rhizome of Acorus tatarinowii. The absolute configurations of 14 were established by computation of specific rotation values. The isolated compounds were evaluated for their cAMP regulatory activity by the AlphaScreen assay.

中文翻译:

来自塔哥A藜的化合物:通过量子计算和cAMP调节活性测定绝对构型

从中分离出一种新的卡丹烷型倍半萜,tatarinowin A(1),两个苯丙烷,他汀类化合物A(2)和B(3),以及一个三降甲素,他汀类化合物C(4),以及15种已知的化合物,包括两对混合物。塔哥A根茎的根茎。的绝对构型1 - 4通过特定旋转值的计算确定。通过AlphaScreen测定评估分离的化合物的cAMP调节活性。
更新日期:2010-05-17
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