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Compounds from Acorus tatarinowii: Determination of Absolute Configuration by Quantum Computations and cAMP Regulation Activity
Journal of Natural Products ( IF 3.3 ) Pub Date : 2010-05-17 00:00:00 , DOI: 10.1021/np900793e Xiao-Gang Tong 1 , Gui-Sheng Wu 1 , Cheng-Gang Huang 1 , Qing Lu 1 , Yue-Hu Wang 1 , Chun-Lin Long 1 , Huai-Rong Luo 1 , Hua-Jie Zhu 1 , Yong-Xian Cheng 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2010-05-17 00:00:00 , DOI: 10.1021/np900793e Xiao-Gang Tong 1 , Gui-Sheng Wu 1 , Cheng-Gang Huang 1 , Qing Lu 1 , Yue-Hu Wang 1 , Chun-Lin Long 1 , Huai-Rong Luo 1 , Hua-Jie Zhu 1 , Yong-Xian Cheng 1
Affiliation
A new cadinane-type sesquiterpenoid, tatarinowin A (1), two phenylpropanoids, tatarinoids A (2) and B (3), and a trinorlignan, tatarinoid C (4), along with 15 known compounds including two pairs of mixtures were isolated from the rhizome of Acorus tatarinowii. The absolute configurations of 1−4 were established by computation of specific rotation values. The isolated compounds were evaluated for their cAMP regulatory activity by the AlphaScreen assay.
中文翻译:
来自塔哥A藜的化合物:通过量子计算和cAMP调节活性测定绝对构型
从中分离出一种新的卡丹烷型倍半萜,tatarinowin A(1),两个苯丙烷,他汀类化合物A(2)和B(3),以及一个三降甲素,他汀类化合物C(4),以及15种已知的化合物,包括两对混合物。塔哥A根茎的根茎。的绝对构型1 - 4通过特定旋转值的计算确定。通过AlphaScreen测定评估分离的化合物的cAMP调节活性。
更新日期:2010-05-17
中文翻译:
来自塔哥A藜的化合物:通过量子计算和cAMP调节活性测定绝对构型
从中分离出一种新的卡丹烷型倍半萜,tatarinowin A(1),两个苯丙烷,他汀类化合物A(2)和B(3),以及一个三降甲素,他汀类化合物C(4),以及15种已知的化合物,包括两对混合物。塔哥A根茎的根茎。的绝对构型1 - 4通过特定旋转值的计算确定。通过AlphaScreen测定评估分离的化合物的cAMP调节活性。