Emerging Roles of Electrospun Nanofibers in Cancer Research,Advanced Healthcare Materials

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Emerging Roles of Electrospun Nanofibers in Cancer Research
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-12-06 , DOI: 10.1002/adhm.201701024
Shixuan Chen ₁ , Sunil Kumar Boda ₁ , Surinder K Batra ₂ , Xiaoran Li ₃ , Jingwei Xie ₁

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This article reviews the recent progress of electrospun nanofibers in cancer research. It begins with a brief introduction to the emerging potential of electrospun nanofibers in cancer research. Next, a number of recent advances on the important features of electrospun nanofibers critical for cancer research are discussed including the incorporation of drugs, control of release kinetics, orientation and alignment of nanofibers, and the fabrication of 3D nanofiber scaffolds. This article further highlights the applications of electrospun nanofibers in several areas of cancer research including local chemotherapy, combinatorial therapy, cancer detection, cancer cell capture, regulation of cancer cell behavior, construction of in vitro 3D cancer model, and engineering of bone microenvironment for cancer metastasis. This progress report concludes with remarks on the challenges and future directions for design, fabrication, and application of electrospun nanofibers in cancer diagnostics and therapeutics.

中文翻译：

静电纺纳米纤维在癌症研究中的新兴作用

本文综述了静电纺纳米纤维在癌症研究中的最新进展。首先简要介绍了电纺纳米纤维在癌症研究中的新兴潜力。接下来，讨论了对癌症研究至关重要的电纺纳米纤维的一些重要特征的最新进展，包括药物的掺入、释放动力学的控制、纳米纤维的定向和排列以及 3D 纳米纤维支架的制造。本文进一步重点介绍了电纺纳米纤维在癌症研究多个领域的应用，包括局部化疗、组合治疗、癌症检测、癌细胞捕获、癌细胞行为调控、体外3D癌症模型构建以及癌症骨微环境工程转移。本进展报告最后评论了电纺纳米纤维在癌症诊断和治疗中的设计、制造和应用所面临的挑战和未来方向。

更新日期：2017-12-06

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