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Cytotoxic and Antimycobacterial Prenylated Flavonoids from the Roots of Eriosema chinense
Journal of Natural Products ( IF 3.3 ) Pub Date : 2009-05-12 00:00:00 , DOI: 10.1021/np900021h Somyote Sutthivaiyakit 1 , Oracha Thongnak 1 , Thitima Lhinhatrakool 1 , Orapan Yodchun 1 , Ratree Srimark 1 , Prisana Dowtaisong 1 , Mayuree Chuankamnerdkarn 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2009-05-12 00:00:00 , DOI: 10.1021/np900021h Somyote Sutthivaiyakit 1 , Oracha Thongnak 1 , Thitima Lhinhatrakool 1 , Orapan Yodchun 1 , Ratree Srimark 1 , Prisana Dowtaisong 1 , Mayuree Chuankamnerdkarn 1
Affiliation
Eight new prenylated flavonoids, khonklonginols A−H (1−8), together with six known compounds including five flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 1−8 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
中文翻译:
细胞毒性和抗分枝杆菌异戊烯基黄酮类化合物的根源雀脷珠属楸
八个新异戊烯化的类黄酮,khonklonginols A-H(1 - 8),加上6种已知化合物包括五类黄酮,lupinifolinol(9),dehydrolupinifolinol(10),flemichin d(11),eriosemaone A(12),和lupinifolin(13),以及一个木脂素,yangambin(14),已经从根部的己烷和二氯甲烷提取物中分离雀脷珠属楸。1 − 8的结构用光谱学方法阐明。评估了这些化合物对小细胞肺(NCI-H187)和口腔表皮癌(KB)人细胞系的细胞毒活性,以及对结核分枝杆菌H37Ra的抗分枝杆菌活性。
更新日期:2009-05-12
中文翻译:
细胞毒性和抗分枝杆菌异戊烯基黄酮类化合物的根源雀脷珠属楸
八个新异戊烯化的类黄酮,khonklonginols A-H(1 - 8),加上6种已知化合物包括五类黄酮,lupinifolinol(9),dehydrolupinifolinol(10),flemichin d(11),eriosemaone A(12),和lupinifolin(13),以及一个木脂素,yangambin(14),已经从根部的己烷和二氯甲烷提取物中分离雀脷珠属楸。1 − 8的结构用光谱学方法阐明。评估了这些化合物对小细胞肺(NCI-H187)和口腔表皮癌(KB)人细胞系的细胞毒活性,以及对结核分枝杆菌H37Ra的抗分枝杆菌活性。