当前位置: X-MOL 学术J. Nat. Prod. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cytotoxic and Antimycobacterial Prenylated Flavonoids from the Roots of Eriosema chinense
Journal of Natural Products ( IF 3.3 ) Pub Date : 2009-05-12 00:00:00 , DOI: 10.1021/np900021h
Somyote Sutthivaiyakit 1 , Oracha Thongnak 1 , Thitima Lhinhatrakool 1 , Orapan Yodchun 1 , Ratree Srimark 1 , Prisana Dowtaisong 1 , Mayuree Chuankamnerdkarn 1
Affiliation  

Eight new prenylated flavonoids, khonklonginols A−H (18), together with six known compounds including five flavonoids, lupinifolinol (9), dehydrolupinifolinol (10), flemichin D (11), eriosemaone A (12), and lupinifolin (13), and one lignan, yangambin (14), have been isolated from hexane and dichloromethane extracts of the roots of Eriosema chinense. The structures of 18 were elucidated by spectroscopic methods. The compounds were evaluated for cytotoxic activity against the small-cell lung (NCI-H187) and oral epidermal carcinoma (KB) human cell lines as well as for antimycobacterial activity against Mycobacterium tuberculosis H37Ra.

中文翻译:

细胞毒性和抗分枝杆菌异戊烯基黄酮类化合物的根源雀脷珠属楸

八个新异戊烯化的类黄酮,khonklonginols A-H(1 - 8),加上6种已知化合物包括五类黄酮,lupinifolinol(9),dehydrolupinifolinol(10),flemichin d(11),eriosemaone A(12),和lupinifolin(13),以及一个木脂素,yangambin(14),已经从根部的己烷和二氯甲烷提取物中分离雀脷珠属楸18的结构用光谱学方法阐明。评估了这些化合物对小细胞肺(NCI-H187)和口腔表皮癌(KB)人细胞系的细胞毒活性,以及​​对结核分枝杆菌H37Ra的抗分枝杆菌活性。
更新日期:2009-05-12
down
wechat
bug