Functionalized spiroacetals have been easily prepared in a one‐pot three‐component coupling process that involves the reaction of pentynol derivatives, salicylaldehydes, and amines in the presence of catalytic amounts of a palladium(II) complex (see scheme). Alternatively, oxygen‐substituted spiroacetals can be obtained by using orthoesters as the third component.

中文翻译：

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一锅多组分级联反应在钯（II）催化下合成螺缩醛

功能化的螺缩醛很容易通过一锅三组分偶联方法制备，该方法涉及戊炔醇衍生物，水杨醛和胺在催化量的钯（II）配合物存在下的反应（参见方案）。或者，可以通过使用原酸酯作为第三种成分来获得氧取代的螺缩醛。