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Pushing the Resolving Power of Tyndall–Powell Gate Ion Mobility Spectrometry over 100 with No Sensitivity Loss for Multiple Ion Species
Analytical Chemistry ( IF 6.7 ) Pub Date : 2017-11-30 00:00:00 , DOI: 10.1021/acs.analchem.7b03629 Chuang Chen 1 , Hong Chen 1, 2 , Haiyang Li 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2017-11-30 00:00:00 , DOI: 10.1021/acs.analchem.7b03629 Chuang Chen 1 , Hong Chen 1, 2 , Haiyang Li 1
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Ion gate is a key buildup for drift tube ion mobility spectrometry (IMS) and its combination with mass spectrometry. Bradbury–Nielsen gate, as the most commonly used ion gate in IMS, possesses a distinct ion mobility discrimination effect due to its depletion features. This impedes the scaling of the ion gate opening time to improve the separation capability of IMS while keeping its sensitivity for multiple ion species. In this work, a Tyndall–Powell gate (TPG) simply composed of two identical wire grids was used to develop an ion gate with nearly no ion mobility discrimination for IMS. Experimental results showed that the TPG features a gate region where the electric field for opening the gate could be enhanced to effectively solve the ion mobility discrimination problem related to it. Meanwhile, enhancing that electric field enabled the TPG-IMS to keep a resolving power over 106 at 100 °C for ion peak with a signal-to-noise ratio up to 800. With that TPG-IMS, baseline separation of two ion peaks, the hydronium and the acetone monomer peaks with a reduced mobility difference of only 0.04 cm2 V–1 s–1, was achieved with no sensitivity loss for the least mobile acetone dimer ions.
中文翻译：
将廷德尔-鲍威尔门离子迁移谱仪的分辨能力提高到100以上，而多种离子物种的灵敏度均没有损失
离子门是漂移管离子迁移谱（IMS）及其与质谱法结合的关键产品。布拉德伯里-尼尔森门作为IMS中最常用的离子门，由于其耗尽特性而具有明显的离子迁移率识别效果。这阻碍了离子门打开时间的缩放，从而提高了IMS的分离能力，同时又保持了其对多种离子物种的敏感性。在这项工作中，仅由两个相同的线栅组成的丁达尔-鲍威尔门（TPG）被用于开发几乎没有离子迁移率歧视的离子门。实验结果表明，TPG具有栅极区域，可以增强打开栅极的电场，从而有效地解决了与其相关的离子迁移率识别问题。同时，对于最不活泼的丙酮二聚体离子，灵敏度没有损失，达到了2 V –1 s –1。
更新日期：2017-11-30
中文翻译：
将廷德尔-鲍威尔门离子迁移谱仪的分辨能力提高到100以上，而多种离子物种的灵敏度均没有损失
离子门是漂移管离子迁移谱（IMS）及其与质谱法结合的关键产品。布拉德伯里-尼尔森门作为IMS中最常用的离子门，由于其耗尽特性而具有明显的离子迁移率识别效果。这阻碍了离子门打开时间的缩放，从而提高了IMS的分离能力，同时又保持了其对多种离子物种的敏感性。在这项工作中，仅由两个相同的线栅组成的丁达尔-鲍威尔门（TPG）被用于开发几乎没有离子迁移率歧视的离子门。实验结果表明，TPG具有栅极区域，可以增强打开栅极的电场，从而有效地解决了与其相关的离子迁移率识别问题。同时，对于最不活泼的丙酮二聚体离子，灵敏度没有损失，达到了2 V –1 s –1。
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