A Mannich-type multicomponent assembly process/1,3-dipolar cycloaddition strategy has been developed for the rapid and efficient construction of a parent tetrahydroisoquinoline fused isoxazolidine scaffold, which was subsequently functionalized using well-established protocols to access a diverse 70-membered library of novel 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-amine derivatives.

中文翻译：

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2,3,4,6,7,11b-六氢-1H-吡啶并[2,1-a]异喹啉-2-胺衍生物的文库通过多组分组装方法/ 1,3-偶极环加成策略制备。

为了快速有效地构建母体四氢异喹啉稠合的异恶唑烷骨架，已经开发了一种Mannich型多组分组装工艺/ 1,3-偶极环加成策略，随后使用公认的方案将其功能化，以访问多样化的70个分子库新的2,3,4,6,7,11b-六氢-1H-吡啶[2,1-a]异喹啉-2-胺衍生物。