Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins,Chemistry - A European Journal

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Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2017-11-28 07:51:34 , DOI: 10.1002/chem.201704410
Xuelei Lai _{1,

2} , Harry J. Wichers ₃ , Montserrat Soler-Lopez ₂ , Bauke W. Dijkstra ₁

Affiliation

Three homologous metalloenzymes—tyrosinase, TYRP1 and TYRP2—catalyze the biosynthesis of melanin in humans, a pigment that is responsible for the pigmentation of skin, eye, and hair. The recently determined crystal structure of TYRP1 provides a structural rationalization of oculocutaneous albinism type 3 related mutations, and gives insight into binding modes of substrates and inhibitors that can guide structure-based design of compounds for pigmentation disorder treatments. This review discusses the current knowledge on the activity and function of the three melanogenic enzymes.

中文翻译：

人酪氨酸酶和酪氨酸酶相关蛋白的结构和功能

三种同源金属酶-酪氨酸酶，TYRP1和TYRP2-催化人类体内黑色素的生物合成，这种色素负责皮肤，眼睛和头发的色素沉着。TYRP1的最近确定的晶体结构提供了3种眼皮肤白化病相关突变的结构合理化，并深入了解了底物和抑制剂的结合模式，这些底物和抑制剂可指导用于色素沉着障碍治疗的化合物的基于结构的设计。这篇评论讨论了有关三种黑色素生成酶的活性和功能的当前知识。

更新日期：2017-11-28

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