Safe‐by‐Design Ligand‐Coated ZnO Nanocrystals Engineered by an Organometallic Approach: Unique Physicochemical Properties and Low Toxicity toward Lung Cells,Chemistry - A European Journal

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Safe‐by‐Design Ligand‐Coated ZnO Nanocrystals Engineered by an Organometallic Approach: Unique Physicochemical Properties and Low Toxicity toward Lung Cells
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2018-01-17 , DOI: 10.1002/chem.201704207
Małgorzata Wolska-Pietkiewicz ₁ , Katarzyna Tokarska ₁ , Agnieszka Grala ₂ , Anna Wojewódzka ₁ , Elżbieta Chwojnowska ₂ , Justyna Grzonka _{2,

3} , Piotr J. Cywiński ₂ , Krzysztof Kruczała ₄ , Zbigniew Sojka ₄ , Michał Chudy ₁ , Janusz Lewiński _{1,

2}

Affiliation

The unique physicochemical properties and biocompatibility of zinc oxide nanocrystals (ZnO NCs) are strongly dependent on the nanocrystal/ligand interface, which is largely determined by synthetic procedures. Stable ZnO NCs coated with a densely packed shell of 2‐(2‐methoxyethoxy)acetate ligands, which act as miniPEG prototypes, with average core size and hydrodynamic diameter of 4–5 and about 12 nm, respectively, were prepared by an organometallic self‐supporting approach, fully characterized, and used as a model system for biological studies. The ZnO NCs from the one‐pot, self‐supporting organometallic procedure exhibit unique physicochemical properties such as relatively high quantum yield (up to 28 %), ultralong photoluminescence decay (up to 2.1 μs), and EPR silence under standard conditions. The cytotoxicity of the resulting ZnO NCs toward normal (MRC‐5) and cancer (A549) human lung cell lines was tested by MTT assay, which demonstrated that these brightly luminescent, quantum‐sized ZnO NCs have a low negative impact on mammalian cell lines. These results substantiate that the self‐supporting organometallic approach is a highly promising method to obtain high‐quality, nontoxic, ligand‐coated ZnO NCs with prospective biomedical applications.

中文翻译：

通过有机金属方法设计的可安全设计的配体涂覆的ZnO纳米晶体：独特的理化性质和对肺细胞的低毒性

氧化锌纳米晶体（ZnO NCs）的独特物理化学性质和生物相容性在很大程度上取决于纳米晶体/配体的界面，这在很大程度上取决于合成程序。通过有机金属自备制备了稳定的ZnO NC，它们包覆有2-（2-甲氧基乙氧基）乙酸盐配体的致密堆积壳，它们充当miniPEG原型，分别具有平均核尺寸和4-5的流体动力学直径和约12 nm的流体动力学直径。支持方法，具有完整的特征，并用作生物学研究的模型系统。单锅自支撑有机金属程序中的ZnO NCs具有独特的理化特性，例如相对高的量子产率（高达28％），超长的光致发光衰减（高达2.1μs）以及在标准条件下的EPR静音。MTT分析测试了所得ZnO NCs对正常（MRC-5）和癌症（A549）人肺细胞系的细胞毒性，这表明这些明亮发光的量子大小ZnO NCs对哺乳动物细胞系的负面影响小。这些结果证实，自支撑有机金属方法是一种具有前瞻性生物医学应用的，获得高质量，无毒，配体涂层的ZnO NC的极有前途的方法。

更新日期：2018-01-17

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