Cu(OAc)2/TEMPO Cooperative Promoted Hydroamination Cyclization and Oxidative Dehydrogenation Cascade Reaction of Homopropargylic Amines,Chemistry - An Asian Journal

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Cu(OAc)2/TEMPO Cooperative Promoted Hydroamination Cyclization and Oxidative Dehydrogenation Cascade Reaction of Homopropargylic Amines
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2017-11-27 , DOI: 10.1002/asia.201701386
Yuanfang Kong ₁ , Kediliya Wumaier ₁ , Yingze Liu ₁ , Chunhui Jiang ₁ , Shuai Wang ₁ , Lingyan Liu ₁ , Weixing Chang ₁ , Jing Li _{1,

2}

Affiliation

A novel and efficient Cu(OAc)₂‐catalyzed hydroamination cyclization and 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO)‐mediated oxidative dehydrogenation cascade reaction of homopropargylic amines has been developed. A library of 1,2‐disubstituted pyrrole derivatives were obtained in good‐to‐high yields in one pot with no step‐by‐step feeding process. This reaction involved TEMPO playing dual roles as both an oxidative dehydrogenation reagent and a ligand. An insight into the reaction mechanism was obtained by using several analytical determination methods.

中文翻译：

Cu（OAc）2 / TEMPO协同促进同质胺的加氢胺化环化和氧化脱氢级联反应

开发了一种新颖高效的Cu（OAc）₂催化加氢胺化环化反应，以及2,2,6,6-四甲基哌啶-1-氧基（TEMPO）介导的同炔丙基胺的氧化脱氢级联反应。在没有分步进料过程的情况下，可以在一个锅中以高到高的产率获得1,2-二取代的吡咯衍生物的库。该反应涉及TEMPO既起氧化性脱氢试剂又起配体的双重作用。通过使用几种分析测定方法，可以深入了解反应机理。

更新日期：2017-11-27

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